St John's Wort and It's Active Prins in Depression, Anxiety - W. Muller (Birkhauser, 2005) WW.pdf

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(( 3. Umbruch 22.12.2004 ))
Milestones in Drug Therapy
MDT
Series Editors
Prof. Michael J. Parnham, PhD
Senior Scientific Advisor
PLIVA Research Institute Ltd
Prilaz baruna Filipovic a 29
´
HR-10000 Zagreb
Croatia
Prof. Dr. J. Bruinvels
Sweelincklaan 75
NL-3723 JC Bilthoven
The Netherlands
St. John’s Wort and its
Active Principles in
Depression and Anxiety
Edited by W. E. Müller
Birkhäuser Verlag
Basel · Boston · Berlin
Editor
Walter E. Müller
Pharmakologisches Institut für Naturwissenschaftler
Biozentrum Universität Frankfurt
Marie-Curie-Str.9
60439 Frankfurt
Germany
Advisory Board
J.C. Buckingham (Imperial College School of Medicine, London, UK)
R.J. Flower (The William Harvey Research Institute, London, UK)
G. Lambrecht (J.W. Goethe Universität, Frankfurt, Germany)
Library of Congress Cataloging-in-Publication Data
St. John’s Wort and its active principles in depression and anxiety / W.E. Müller, editor.
p. ; cm.-- (Milestones in drug therapy)
Includes bibliographical references and index.
ISBN 3-7643-6160-3 (alk. paper)
1. Hypericum perforatum--Therapeutic use. 2. Affective disorders--Treatment.
I. Müller, Walter E. (Walter Erhard), 1947- II. Series.
[DNLM: 1. Hypericum. 2. Phytotherapy. 3. Anxiety Disorders--drug therapy. 4.
Depressive Disorder--drug therapy. QV 766 S143 2005]
RS165.H95S73 2005
615’.323624--dc22
20044062277
Bibliographic information published by Die Deutsche Bibliothek
Die Deutsche Bibliothek lists this publication in the Deutsche Nationalbibliografie;
detailed bibliographic data is available in the Internet at <http://dnb.ddb.de>.
ISBN 10: 3-7643-6160-3 Birkhäuser Verlag, Basel - Boston - Berlin
ISBN 13: 978-3-7643-6160-0
The publisher and editor can give no guarantee for the information on drug dosage and administration
contained in this publication. The respective user must check its accuracy by consulting other sources
of reference in each individual case.
The use of registered names, trademarks etc. in this publication, even if not identified as such, does
not imply that they are exempt from the relevant protective laws and regulations or free for general
use.
This work is subject to copyright. All rights are reserved, whether the whole or part of the material is
concerned, specifically the rights of translation, reprinting, re-use of illustrations, recitation, broad-
casting, reproduction on microfilms or in other ways, and storage in data banks. For any kind of use,
permission of the copyright owner must be obtained.
© 2005 Birkhäuser Verlag, P.O. Box 133, CH-4010 Basel, Switzerland
Part of Springer Science+Business Media
Printed on acid-free paper produced from chlorine-free pulp. TCF
∞
Printed in Germany
ISBN 10: 3-7643-6160-3
ISBN 13: 978-3-7643-6160-0
987654321
www. birkhauser.ch
Contents
List of contributors
.....................................
VII
Walter E. Müller
Introduction and historical outline
...........................
1
Kurt Hostettmann and Jean-Luc Wolfender
Phytochemistry . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Marco Gobbi and Tiziana Mennini
St. John’s Wort and its active principles in depression and
anxiety – A critical analysis of receptor binding studies . . . . . . . . . . .
Kristina Treiber and Walter E. Müller
Effects on transmitter uptake and their cellular and molecular basis . .
Jan Kehr, Sven Ove Ögren and Takashi Yoshitake
Modulation of neurotransmitter release and metabolism
Carla Gambarana and Daniela Giachetti
Efficacy in behavioural models of antidepressant activity
5
21
31
..........
47
.........
59
Michael Nöldner
Comparative preclinical antidepressant activity of isolated
constituents . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Shyam S. Chatterjee
Hyperforin and efficacy in animal models for anxiety and cognition . .
Mario Wurglics and Manfred Schubert-Zsilavecz
Pharmacokinetics and biopharmaceuticals . . . . . . . . . . . . . . . . . . . . .
73
85
99
Siegfried Kasper
Clinical efficacy in depression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 123
Hans-Peter Volz
Clinical efficacy of St. John’s Wort in psychiatric disorders other
than depression . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 133

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