1949_condrau_1463_1.pdf

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CUP_T
ABST_6TS
AND EXCERPTS NO. 85
March
1950
Page 1
RE:
AUTHOR:
AFFILIATION:
TITLE:
LSD
LSD
!Tr.3
Glen C o n d r a u
Psychiatrische Universitatsklinik,
Zurich
KLINISCHE ERFAHRUNGEN _n_l
GEISTESK_K_N
MIT LYSERG-
I!
11
SAURE-DIATHYL_IID
(Clinical experiences in mental patients with
lysergic acid-diethylamide)
Acta psychiat.et neurol. 22__: , 1949
9
Digest Neurol.& Psychiat.,Inst.of Living I__: 149 (March)
1950
\
SOURCE:
ABSTRACTED
IN:
COPY:
"In 1943, Hofmann, in Basel, first established
the re-
markable psychic effects of the ergot derivative Lysergic acid-diethylamide
(LSD).
Using the substance in normal and psychotic individuals,
Stoll found that LSD
produces an intoxicated
state of the acute exogenous reaction type.
Besides
motor and vegetative
symptoms there were disturbances
in perception,
particularly
visual hallucinations,
accompanied
by a mild disturbance
of consciousness
but
partly maintained
introspection.
The thought process showed marked distractibility
and acceleration,
the mood varied from euphoric to depressed,
and memory disturb-
ances (temporary) appeared as an after effect of the intoxication.
A most signif-
icant propSrty of LSD is its effectineness
(misspelled) in infinitely small doses
"_.
of_20-30
gamma(0.00002-0.00003
g).
The author reports further observations in 30 psychiatric
cases (refractory to all treatment) and 7 normal individuals.
The effects of LSD,
similar to those observed by Stoll, can be summarized as follows:
motor disturb-
maces (ataxia, positive Romberg, broad gait, indistinct
speech, change in hand-
writing);
gross neurological
disturbances
were lacking but some cases showed an
increase in tendon reflexes;
vegetative
symptoms;
disturbances
of visual and
auditory perception
(intense color experience,
misinterpretation
of noises).
A
special disturbance
of basic consciousness
was not observed outside of the feeling
of intoxication.
Capacity for self-criticismwas
never lost.
The stream of thought
was lig_iened,
accelerated
and easily distracted,
although there was a tendency
to return repeatedly
to a certain theme.
The mood changes involved intensification
of the previous basic mood.
There was a definite decrease in power of concen-
tration, though not pathological.
The mental
patients
included
lO paranoid
schizophrenics,
i
6 catatonics, 5 hebephrenics, 2 simple schizophrenics, 2 propfsc_izophrenics,
1
schizoid psychopath,
1 paranoid-manic-depressive
mixed psychosis, 2 endogenous
depressions,
1 progressive
paralysis.
These patients
showed a much greater re-
slstance to the effects of LSD and a better tolerance to it han did the normal
controls.
In 19 of the 30 cases the dosage used was ICO gamma and more, and in
one case 280.
Vegetative
symptoms were most prominent in these patients (feel-
ing of we_kness,
fatigue, nausea, dizziness,
headache, paresthesias,
hyper-
salivation, perspiration,
circulatory
disturbances,
etc.);
neurologically,
motor and ataxic disturbances were occasionally
observed (in I case, athetotic
movements,
often compulsive
laughter, which points to diencephalic
involvement).
The disturbances
of perception,
consciousness
and personality
were less marked
inthe
psychotic than in the normal subjects and the LSD intoxication was milder
with
reference
to onset and duration of effect.
The therapeutic possibilities
of
the_ drug could not be determined definitely and conclusions
could not be drawn
Page2
L
i
;
on its value for differential diagnosis.
In view of the resistance of mental
patients
to LSD, the question
arises
whether a substance
s_ilar
to LSD is
etiologically
involved in psychoses."
C 0 M M E N T: LSD, though one of our investigational substances, offers nothing
of direct promotional value. It is possible that the drug may eventually find
use for experimental induction of psychotic states. For previous papers by
Kauders and Nickerson see C.A.& E. No. 77, p. I and No. 80, p. 1S.

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