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(_102a)
M
320 Psyche
LSD
No.]2.a
IZSHON, H.J., RINKEL,
M.,
SOLOMON, H.C.
ta
rat
.
26,33 (1952)
SUMMARY
l. Observations
are reported on
the mental changes
in normal
adults
produced by d-lysergic acid diethylamide
tartrate
(L. S. D.).
geventeen experiments
were done on volunteers,
l0 men and five
women, with an
age
range of 19 to 48 years.
Two of the women
underwent
two experiments
each. The drug was given by mouth,
asually in dosage of _[gamma per kilogram of body weight.
2. Besides subjective symptoms,
alterations
were observed in
the
following
areas:
thinking and speech; emotion, mood and af-
fect; sensory and time perception;
behavior; morbid ideas and sen-
sory experiences;
and neurological
signs. Thereaction
exhibited
three phases lasting
a
total of 12 to 16 hours; in
some subjects a
fourth phase,
a_
a post-l,. _.
D.
effect
lasting one to
several
days,
was
seen.
3. The L. S. D. reaction showed some ag.pects of an exogenous
toxic
picture.
Even more impressive, however, was the simulation
of
schizophrenic
reactions
and manifestations.
Simple schizo-
phrenic and turmoil
states were common.
Transient
paranoid
trends were frequent.
Various isolated findings in schizophrenia
such
as negativism,
ambivalence,
blocking, and
unexplained
smil-
ing were witnessed.
Scbizo-affective
and manic-like states were
also
encountered.
Cathartic
ventilation was
seen
in only one
sub-
ject.
The reaction was not specific, and the extent to which it was
dependent
upon the basic personality
of the subject was undeter-
mined.
4. The clinical effects of L. S. D. imply involvement of the
higher or highest centers of the central
nervous
system, and per-
haps of lower levels of the nervous system
as
well.
5. Further
study
of L. S. D. is indicated because of the remark-
able
simulation of findings seen in schizophrenic
and
affective
psy-
choses
on
administration
of an amazingly
small
amount of this
sub-
stance by mouth.
_
(K
_9)®_

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