1954_abramson_1531_1.pdf

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Abstract
and file card
M 500 properties_ Siamese fighting fish
M 340 instincts
effects
LSD Noo66 (§102a)
A2_LMSON_H.A.,
EVANS,L.To
(BioloLabo, Cold Spring Harbor, I_ng Island, New York)
_rgic
acid dieth l_mide
(LSD 2_0_):
IIo Psychobiological
Qn the Siamese fiEh_o
Science 120,990(1954)o
_OBLEM_
The vegetative_ motor and behavioural responses
Siamese fighting fish (Betta splendens) to LSDo
l_!_0D _ DOSAGE:
of the
Groups of 4 fish exposed to 100 mlo of concs o of
I_g/ml_ 5/_g/ml_ 25/_g/ml and 50/_g/ml LSD for ¼_6 hours and then
transferred to spring water° Effects noted 6 hours after removal
from the drug° Studies also made with untreated controls°
_SULTS:
Quantitative differences were noted between the responses
of adult and juvenile fish° The juveniles were far more sensitive°
The characteristic responses to LSD were_ l) Backward mo_ements_
2) Head up, body usually suspended vertically_
3) "Cartesian diver"
effect,
4) "Barrel-roll" effect,
5) "Trance_like" effect_ 6) Slow
amd deliberate movements_
7) "kinking" of body_
display and 9) Pigmentation effects°
Recovery
stupor_like
8) lateral poetural
reaction'_ The fish slowly returned to normal from the
state induced by LSDo Complete recovery within 1 day
(low dosage) or 1 week (high dosage)° In many cases LSD altered
the social behaviour° (This will be reported elsewhere°)
The fish could be roused from stupor by an attacking male and
might even counter-attacko After a brief battle there was an
Inmediate relapse into stupor°
Betta has essentially normal activity in spring water containing
am much as 25% urine for at least 44 hours_ It may thus be possible
to detect LSD and other ergot drugs in urine and other body fluids°
Not a single fish was lost owing to the effects of LSD_ regardless
of
the dosage used _ even after the injection of 50_g
om_al
musculature°
into the
_T:
The effects of LSD on aquarium fish were first investigated
in our laboratories in 1952 (CERLETTI_ unpublished findings), and were
found to be practically identical with those reported in the present
_ro
However, the effect on motor functions is not specific to
_0 _ The effect of LSD on melanophores in the fish is of greater
value
as it enables a differentiation to be made between LSD_like
a_stanceso
Methods are now available
(serotonin antagonism
of LSD)
to demonstrate the presence of LSD in concentrations one thousand
times as small as those possible using fish° The distribution of
LSD in the organism has been studied by means of this method and the
results will be published shortly
(LSD exhibit, Federation Meeting_
San Francisco,
April1955o)
!
(LSD_ IIo Psychobiologische
LSD_Konzentrationen
Wirkung
auf siamesische
Kampffische)
von
meaischen Kampffischen
(Betta
Reaktionen und Ver_nderungen
glauben_ dass derart LSD und
derivate im Urin und anderen
nurl _/cc Quellwasser rufen bei sia-
sple_dens)V" vegetativ-motorische
des Verhaltens hervoro Die Verfo
mSglicherweise
auch andere Mutterkorn-
KSrperfl_ssigkeiten
nachgewiesen
werden kSnneno _Die Wirkung von LSD auf Aquariumsfische
wurde erst-
mals in unseren Laboratorien im Jahre 1952 geprttft (CERLETTI: un-
ver_ffentlichte
Ergebnisse);
sie waren praktisch identisch mit den
in dieser Arbeit publizierteno Allerdings ist die Wirkung auf die
Motorik nicht spezifisch ft_r LSDo Wichtiger ist die Beeinflussung
der Melanophoren beim Fisch durch LSD, da dies_stattet,
LSD-_hu-
li_he Substanzen zu differenzieren.
Heute stehen Methoden zu Ver-
ft_ung_ welche noch 1000fach kleinere Konzentrationen
nachzuweisen
gestatten, als es mit dem Test am Fisch m_glich ist, _mlich
mittel|
des Serotonin-Antagonismus
des LSD. Mit dieser letzteren Methode
wurde die Verteilung des LSD im Organismus studiert, und die Resul-
tate gelangen demn_chst zur Ver8ffentlichung
(LSD exhibit, Federa-
tion Meeting,
w5 (_057)
San Francisco,
April
1955).J
NKT/Dr.Ce/DroBs/bh
155 _
j

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