1953_bradley_1498_1.pdf

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.... ginal and file oard
amphetamine
(_65e)
N
2'70
_L_btttu_te
(§109)
anaesthesia
Mt_,
P.B.,
_,
J.
(Dept.of
Experimental
Psychiatry,
Medical
School,
Bi_)
Ihe
effect
of aml_hetamine
and D-lyser_ic
acid
diethylae_e
i_
_
25_
t_e
electrical
activlty of the
bra/n
of
the conscieus
oat
-
1 P(1 3).
_e
e_eet of DL-amphetamine, its D- and L-isomers, and of D-lyser_c acid
_ethylamide
(StoU, 1947) on the electrical activity of the brain
has been
'etudied in
the conscious unrestrained animal, and in acute experiment. Large
:_ses
of DL-amphetamine
(3-5 mg/kg
by mouth)
produced
rhythms not unlike
_ose
seen
in
the norms]
alert
animal,
i.e.
low amplitude, diffuse, fast (15-30 c/s)
activity
in all regions. There
was
also a corresponding change in behaviour,
•
e animal becom;ng
more
attentive, and,
in
some
instances,
excited. The
eertical
response to rhythmic photic
stimulation,
recorded
over the
visual
wea,
was
increased
in amplitude at all
frequencies between
2 and 25 per sec,
The effects of
D-lysergic
acid
diethylamide
(15-'25
vg/kg
by mouth) o_
electrical
activity
and behaviour were similar to those of DL-amphetamine,
but
no change
in
the response to
photic
stimulation could be observed
with this drug. The effects of barbiturate
anaesthesia (pentobarbitone
110
mg/kg) on the electrical activity of the brain
remained
unaffected by
amphetamine
when
recorded at the cortical
level.
There was, however, some
mcreaee in
the response to photic stimulatioa at the level of the
lateral
_nieulate
body. Large doses of D-lysergic acid
_ethylamide
(50-100
_g/kg)
eompletely abolished the electrical activity characteristic of moderate barbi-
turate anaesthesia, though
leaving
the depth of anaesthesia apparently
Imaffected.
The characteristic waxlng and waning activity seen
in
the corticogram of
the brain sectioned
in s_u
at the level of the 1st cervical vertebra (Bremer,
1938)
was abolished
by
intravenous
amphetamine in doses of 1.5-3
mg/kg.
This
_tivity
was restored
by
section at midbrain level
in
the same preparation,
sad
remained
unaffected by further injections of amphetamine. D-Lysergic
ae_d
diethylamlde in doses
of up
to
100
vg/kg
had
no effect on the
electrical
aotivity of either of these acute preparations.
The effects of amphetamine
and D-lysergic acid
diethylamide
on the
corticogram thus dii_er from atropine, L-hyoscyamine and
physostigmine in
their
dependence
upon
mesencephalic
or spinal connexions. Again, there
is
better correlation between electrical
activity
and behaviour in the case of
amphetamiue and D-lysergic
acid
diethylamide than there
is
with atropine,
L-hyoscyamine
and physost_nine.
Amphetamine
may
act on receptors.
The
differences
between
the
effects
of
D-lysergic
acid
diethy|a_fide
amphetamine,
outweigh any common features shared by these two drugs,
point to probable
differences
in their mode of action.
REFERENCES
Bremer, F. (1938).
L'activltg
_ectrique
de l'&orce cb'_brale.
Paris: Hermann
Magoun, H. W. (1952).
Res. Publ. Aes. Nerv. MenL Dis.
279. 480.
Stoll, W.
A.
(1947).
Ecltweiz. Arch. Neurol. Psyc_iat.
60r
80,
_:_
_
/bh
XO 3

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