1953_gaddum_1506_1.pdf

(102 KB) Pobierz
tract and file card
,-
7_
----No_j-_.j;j--
_
_
_
_
L_D
No0_3
(§102a)
C50
bronchi_ constriction
serotonin
(_72b)
_U)DUM_
JoHo_
_BB_
Co0o, SILVER,_ Ao_ SWAN_
AoAoBo
(_eptsoof Physioloand Pharmaco_o _ Univoof Edinburgh)
_Evdroxy. tr_ptamine_ Pha.r_..coloK±ca.!
action and destruction
fused
lungs o
Q_art oJ oexpo
Physiol
o_ 255 (1953 )o
in
m0BLEM;, Studies by one of the authors showed that hydroxytryptamine
_RT) (= serotonin) caused pulmonary vasoconstriction in the anaesthet,=
Ized cat° An investigation was therefore made of the action of HT on
_e catQs lungs perfused with blood and the effects of DHE_ LSD and
adrenaline o
__._
The method employed was similar to that used by DALY (Quart oJo
e_poPhysiolo28_55%19_8)
for perfusing monkey_s lungs°
"
m_SULTS_ In
+_c
preliminary e_phs_ the usual effect of HT was a fall
_
carotid pressure_ sometimes '_bilowed by a rise° The initial depress_
er effect was considered due to an.increase in the resistance in the
_nary
circulation° The exptso on the perfused luugs confirmed that
Y%Me rise in pulmonary pressure was ,due to direct action of the pulmon_
-ary
vessels° The ioao in.joof HT ca_sed both bronchoco_str_ct_on and
vaso._constrictiono The vasomotor response was variable°
Adrenaline injected _
°
_mmedlate_y before HT abolished or reduced the
_onchoconstrictor
response in a_l exptsobut had a less._onsistent
effect on the vasomotor _esponseo
In 3 e_.ptso after a number of consistent responses to HT had been
9
e_tained_ _he effect of DEE on subsequent injections of H;'was noted°
'
la a cOncoof i/_/ml blood DHE first reversed and then. abolished the
vasomotor response to 20/_g HTo Larger doses
could
still produce vaso=
e®nstriction although th_
response
was small° The bronchcconstrictor
&_tion was completely _b_,lishedo
LSD also antagonized
the effects of HT on the lungs in a _Oncoof
bloodo
Adrenaline increased p_!monary arterial pressure in 4 expts_ _'eo.u_d
it in 2 exptsoand produc_, a rise f,_lowed by a fall in one° It always
emused bronchodiiatailOno After DHE_ adrenaline _nvariab_y produced
vmmodilstat_.on and the hcon_hod1_Latat_on normally obser_edo
The RT_eq_valent
of p._asma wss determined by extrac_ion with
_etone
and assay in %he xa_ aterus_, in <_omparisoo w_th syntheti¢ HTo
Im
the presence of 0ol _g LSD the e_fe_ts of HT and of extract were
_mpletely , abolished, but the muscle stl_l ga_e a larg_
l
_espons_
_to
i
mUo of ox_tocino COMMENT_ See comment on abstra<,,_
G,ye_po698
_( _);_=_
_mw(_
WOOLZ_Y)
_._ago_._
_
_o se_ot_on_,_o
/th
5_,_.
®23
_

Plik z chomika:

Inne pliki z tego folderu:

Inne foldery tego chomika:

Zgłoś jeśli naruszono regulamin