1953_lovell_rrh_1490_1.pdf

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Abstract and file card
VI LSD Noo27
(§102a)
Q
63 rheum&toid
arthritis
S 67 tuberculin sensitivity
A 27 eosinophil count
A 210 erythrocFte
sedimentation
rato
_DVELL_ R.RoH,_ OSBOR_E) J.A.) GOOD_'_hN_,_,C _._SJDSON, B o
• ° S
"
(l_heumatism Researc_h Unit, Dept._d.
_÷ _'_
_' rT _
London)_ Ascorb_luc
ose-l-_
___er_c
_acid
_lamide
_n rheumatoid arthrltL o
PROBLEM"
LONG et al.(Lanoet
262,902,,1951) postulated
±°hat
f s,ctors influencing
experimental
tabe__fL_n
hypersensitivi_
lht
also influence arthritis _m man_ The effect of LSD and
_
glucose_l-phosphate_
which modify experimental
tubere_flin hyper _
sensitivity in the guinea-pig, was st.ldied in cases of rhe_matold
srthritiso The effect of ascorbic a,_id depletlo_ o_ satcration
was also investigated_
MATERIAL_
l0 patients with rheumatoid arthrit_e _n£I I with poly -
arteritls
nodosa
(3 treated with ascorbie acid_ 4 _i,th glucose-
1-phosphate
and 4 wifih ISD),,
METHOD:
All patients received
acetyls_licy]:ic; a<_i,_d_ly
and
s_c_e--_'[mes
tab_codeine CO o.BoP_ Arthritis ass,_ss_d _t ]east twiCe _
a week in Io__ studies and daily i_ sho_t standingsb_ measurements
of heat, swelling, tenderness and fun_t_ona_ i_apa_i__y Of' _ointso
The ..patlentstreated wi+_h ISD and g.tu_ose-]_oho_o_te,, re0elved ....
,,
__ ,
dummy preparations for up to _ days before t_eatmeo/to Tuberculin
reactivity tested by intradermal inJ. of p_rified prote_
derivat o
_,eo Eos_:._oph_ls counted twice weekly° Erythro_j_ _e sedimentation
rate
(ESR) measured once weekly,:
DOSAGE:
LSD 0o005-0.1 mg daily (fo_ _-ql days/ by m,outh_
nl_cos__,
e-_e
4-800 mg daily b7 _Vo_n_e
t_ons o__ drip°
Jorbic acid given ora/ly_
_SULTS_
I_ Ascorbic acid_
In 4 c_ase_3:_°he'_!,_._._i/_
arthritis
w'as
not influenced by asoorbic acid depletlo_ o_ _e%_ at L_n_ nor did
these factors appear to influence the tberapet_ti_ _ffe_t_ of
Cortisone and ACTH_ In one patient rea<_t_i_
%_; Tub_<_t_a
in _
_rease_ during depletion of asoorbi_
ao.id_,
decrea_e_] after sat_.r
o_,
ation, and decreased still further when AC_ven_
When ACT}{
was withheld.the reactivity to tuberculin rose to a level compal:_
able to tha_attained
daring ascorbio _c:_d deplet_on_
2o Ql_ose-l_ph_p_te_
'In tlbe d6Ses iise_ gIfic_e-l-
phosphate did not _nfluence the e6urs_ of the art_ritis in 4
patients or the size of the tuberc_ol_n response in the 2 pats_
tested. No effects on eoeinophil counts or ESR.
3. LSD _ In the doses used LSD did not influence the
course of rheumatoid arthritis _m 4 patients or the size of the
tuberculin reaction in the 2 pats. tested° No effect on eosino_
:
,
'
phil counts or ESR_
....
CO_ENT. _
No previous
report
has been published
on the effect
LSD
in rheumatoid arthritis. The investigation was
made
because
an analogy between experimental tuberculin
hypersensitivity
in
the gulnea_pig and the tissue reaction in rheumatoid
arthritis
was p_tulated. CORNFORTH and LONG (LSD No o16) showed that
LgD
d_m_nished sensitivity to tuberculin in guinea-pigs
o
(Ascorbins_ure, Glucc_e-L_phosphat und
LSD
bei Rheumatoidarthri-
Bei
i_
Kranken mit Rheu_atoidarthritis und einem mit
P6_rlltis
nodosa wurde
die
Wirkumg gewisser Maesnahmen b_o
,
Subs_en
untersucht_ welehe die Tuberkulinallergie des Meer-
schweinche_ beeinflussen. Bei 3
Patienten
beeinflass%e Vit oC-
_:
f_ele
Ern_mg
und S_tti_:_ mit
Vitamin
C
nieht den Verlauf
d@r
Arthritis oder die WirbmZ yon
Cortison
oder ACTH. Ebenso
batten Glucose-L-phosphat und
LSD
bei Je 4 Kranken keinen Ein-
fluss a_f die Arthritis und die
-
bei Je 2 Kranken gepriLfte
T_berkulinmnpfindlichkeito Sie ver_nderten auch
nicht
die Eosino_
philenzahl und die Erythro_ytensenkungsreaktiono _B_glo LSD,
Glukesephospha_und Tuberkulinm_pfindlichkeit
vgl_ LSD
Nrol6_
t
Rapport
6/12 oJ
!
!
b
(Acide ascorbique_
rhu_atismale)
phosph_%e
du
L-glucose
et LgD
d_ns
l_sm%hrite
..
Dans i0 cas d_ar_ite
et i cas de polyart_rlte noueuse_
investigations sum lWeffet
de
certaines mesures ou substances
_n_luen_ant I_allergie tuberculinique
du
cobaye_ Dsam 3 cas _
"
r_gime _ans vitsmine C et la saturation avec vitsmine C
n'in-
fluencent _i le cours
de
l_arthrit_
ni
l_action
de
Cortisone ou
ACTHo
Daus
4 cas_ le phosphate du L_glucose et le
LSD n_influ_
encent ni l_arthrlte ni la sen_ibilit_ _ la tuberculine (cette
der_,_r_._st e.wamnin_eams 2 eas)o
En
outre_ Jisne
modifien% ni
d
2,e
nombre des _osinoph_les
ni
la s_dimentation
globulaireo
'
[Q_t
_LSD_ phosphate
du
glucose
et
sensibilJ_t__ la tuber-
_e_
Voaussi CORNFORTH et LONG,
LSD
No 16_ rapport 6/12_
(K 69)
NKT/DroSpi/DroBs/bh
653
@,_

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