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Abstract

and

file

card

M _561 catatonic stupor

VI LSD No.64 (§102a)

amphetamine

amytal

mephenesin

ELKES,

(§65e)

(§lO5f)

(§159e)

Co,

BRADLEY,

on

Jo, ELKES_

of some

PoBo

(Deptoof

ExperoPsychiatry_

Hospo,

Bir_fLugham)

bra_

of the

Medc.School_Univoof

The effect

and

Bi#mingham,

dru_s

and Winson

the el.ectrical

London

Green

activity

on behavio .uro

JoMentoSc._

I00_125(1954).

In this

9aper

read at the Annual

Meeting

of the Medico_Psycho-

logical Association

held at Barnwood

House, Gloucester_

on lOth July

1953,

reference

is

made

to finding_

previously

reported

(Bradley,

The

mg

and

LSD

54;

Bradley and Elkes,

LSD

54a_

Bradley

et al_

LSD

35)°

following

observations

have not been previously

reported°

The

effects

of amytal

(750-1000

(120-.240 mg

ioVo),

amphetamine(7-15

in saline),

iovo ), mephenesin

mg given as 5% solution

LSD (60-100_g

by mouth) were com_red

in 9 eases of catatonic

stupor°

The mental

response

was assessed

in terms of

verbal

productivity

and

of

drawing°

pulse

rate,

The

foot

somatic

changes

recorded

included

blood

pressure_

tone

temperature

(multiple

thermocouple)_

muscle

(measured

as

an

in flexors

of

elbow)

and

sweat

and

secretion°

showed

There

was

itself

better

than

was

of drawing°

in foot

optimal

The well-known

increase

correlation

between

between

effect

this

of s_nytal on accessibility

and

a rise

An

Of verbal

productivity

change

tones

temperature

mental

accessibility

-s.ndmuscle

response

only

rarely

accompanied

by full

ing of the amytal response

with

with

not

neostigmine

modify

Amphetamine

common

(0°5-0°75

decreased

the amytal

response_

muscular

repeated

relaxation.

There was blunt-

administration°

PreL_edicat_

(1 mg

unlike

soco)

did

mg SoOo)

or physostigmine

a finding

accessibility_

muscle

to

its

more

effects in normal

subjects°

Mephenesin

regularly

reduced

or foot temperature°

produced

8

response

LSD

tone.with,_ut c_henging

itself

and

unlike

that

accessibility

peculiar

seen with amytal or amphe%amineo

_[_e

response

was characterized

by

unmotivated

laughter and cIving _ bizarre

and uncontrolled

behaviour

and an apparent

activation

of hallucinatory

and delusional

material°

COMMENT_

No previous

reports

have been published

on the effects of

LSD

in catatonic

stupor@

w8 (K7029)

NKT/bh

1254

_3_

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