1955_bhattacharya_4004_2.pdf

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_tract
and file card
antagomdsm to serotonln (§90a)
C 52 bronchial musculature
lid No.ll9 (§102a)
DHE (§75f)
;'
Gy (_75d)
_TACNARYA,
B.K.
(_pt .of Pharmacol., Univ.of Ghent, Belgium; Prof.C.Heymans)
& _macological
study on the
effect
of 5-hydroxytryptamine
antagonists on the bronchial musculature.
Arch. internat, phar macodyn. th 6rap. 102 ,357 (1955 ).
Antagonistic studies
against
5-hydroxytryptamine
using isolated guinea-pig
lung.
"l-'he
following
findings.
and
have been conducted
is the summary of the
I. 5-Hydroxytryptamine
(sHT)
is a potent
bronchoconstrictor.
It reduces the flow of perfusion fluid due to constriction of pulmonary
vessels.
z.
Adrenaline and isopropylarterenol
are the two most active broncho-
dilators.
Unless given in a larl_e dose, the effect is short-acting.
Nora-
drenaline
is
much
weaker
than adrenahne
bronchodilator
and antagonist
to
5HT.
and
isopropylarterenol
as
3. Lysergic acid diethylamide
(I,SD) is an effective antagonist
to
5HT, but
the
margin between curative and
toxic
dose
is
narrow.
The
antagonism
is practically irreversible.
4. Dihydroergotamine
requires
a ]larger dose
than
LSD to be effective
as an antagonist to 5HT.
It has also a prolonged action.
Ergotamine
is much weaker
than
dihydroergotamine
as an antagonist to 5HT.
5" Dibenamine
and Regitine (phentolamine)
are antagonist to 5HT
in high concentrations.
The effects are temporary and in half hour
the
response to 5HT reappears.
6.
Atropine
even in high concentration
is a feeble antagonist
to
5HT.
7. Antihistamines
like Phenergan
(mepyramine)
are not active.
8. An anti-cholinergic
butyramide
methyliodide
induced bronchospasm.
(promethazine)
and Neoantergan
compound
z,z-diphenyl-4-diiso}-,ropylamino-
(R7q) is a feeble antagonist
against 5HT

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