1955_cooper_3975_1.pdf

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_-_vLSD No.90 (§102a)
_A
Chlorpromazine
(§97a)
_OOPER,
H.A. (Rainhill
Hosp.,
M 377 psychoticeffect
M 500 delayed
M £05 EEG
near Liverpool)
reaction
_ucipogenic
dru_s.
_
Lancet,London 268, 1078 (1955)
_
Sm,--Pro_essor
Elkes
and
his colleagues have called
attention
in their letter of April 2 to the
dangers
of
treatment
with lysergic
acid
dietbyhtmide
(LSD 25).
Little
has
been
published _bout
the
delayed reactions,
the report
by Sandison et
al.
_ being'a
notable
exception.
I should therefore
like to record my interim findings
of
some
of
the
phenomena.
Although they
are based
on
limited experience, they ,nay serve as
a
warning, and
the
problems
involved
call
urgently
for investigation.
The
8
patients
in this
series
received
LSD
orally
in.doses
of
50-500
y while
fasting.
An
interval
of at least
seven
days
separated
doses
after
the
trial
ones.
Patients
were
allowed
to
react
with
the
minimum
of
interference
necessary
to prevent
injury
or accident.
Accounts
of
experiences
were
obtained
late
on the day of administration
in
some
cases,
but it was
found
better
to
get written
reports
later
and supplement
them
by oral discussion.
Experience
during
the
acute
phase
followed
the
usual
pattern,
but
personal
experience
was
dominant,
colouring
even
the
early
toxio
tmllucinatory
patterns;
sometimes
dream-like
situations
were
acted
out
violently,
leading
on
from
dreams
before
treatment
began,
and
calling
for protective
mmm_
_
:o
:=:
_:
;_,
_;
.,
.-
i!:
!:
i

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