1955_fabing_1541_1.pdf

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_A_tract
and file card
M 577
hydro chloride
psychotic effect of ISD
(§105.._)
VI LSD NOo76 (§102a)
o(
- (4_piperidyl)
FABING,
HoDo
benzhydrol
(Cincinnati_ Ohio)
hw,,,,blockir_
_
so
a_ln_t
the d_tr_lopm_l_
T_i,2os(1AS)o
_f
LgD_25
ps.vehos1_o
O_-[4=piperidyl)benzh/drol
centrals$imulation
producedin
hydrochloride prevenfs or dimi_i.qh-
themice by
various
agents
includ-
ing amphetamSne_ morphine_ cocaine and Meratrano In some mental pats°
the drug has exerted dramatic effects and a study was therefore made
of its possible use to block the psychosis produced by LSDo
]eTHOD - DOSAGE:
see Results°
_LTS:
100/_g LSD given to 2 healthy men produced typical psychotic
responseso In the first_ LSD caused a psychosis _Asting 5_ hours° In
the 2nd_ ISD produced a distressing agitated paranoid state and a!..=_t
catatonic withdrawal that lasted more than 15 hours° Beginning on the
_zt day, the 2 men were given the blocking agent orally_ one receiv-
ing I0 mg boiodo and the other 5 mg boiodo for 1 weeko 100_g LSD was
taken againo The ist subject reported that the effects of LSD
were markedly different_ There were no hallucinations and he felt
_
h_zhad the situation under
control°
The 2nd subject reported
_t
the experience, although similar, was very different° He felt
that
he had been able to fight successfully against the I_D experience°
The blocking agent did not block the visceral effects of LSDoNausea,
a vague feeling of numbness in the limbs, tightening of the jaws,
d_y mouth, oonjunctival injection and sweating of the extremities
were noticed on both occasions_ No significant changes were noted
in pulse_ Bo.P__ respiration and pupillary size°
One month later, ISD was given to both subjects° Psychotic reac-
tlons of the original type developed in both instances° In the 2nd
Oaae, it was abruptly terminated by the blocking agent given ioVo
/In
5 of 6 subjects (5 F,
5
M) given pretreatment with the block-
ing agent, iO0.x_g LSD produced no psychotic state or only fragment--
ary or fleeting manifestations such as attention defect (5 cases),
, es ivelaughter(2 cases),depress±o s mood level (l ase),
of
fleeting visual hallucinations and distortion of spatial
relation-
lhip (I case) and
nausea
(3 cases),_The dosage of the blocking agent
varied from i0-50
mg
daily for a week° The 6th subject, who had
recelved iO mg of the blocking agent daily for a week prior to LSD
developed
a psychotic response° Subsequently, he was given 50 mg of
the blocking drug daily for a week; when lO0_g ISD was then admin-
istered_ it had no effect° - Observations on 2 subjects suggest that
mescaline-induced
psychoses can be blocked in a similar wayo_a_.
_

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