1955_fabing_4009_1.pdf

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_I LSD NCo125 (§102a)
•
Frenquel
(§illw)
M 37"7 psychotic effect
_ING,
HoDo (Cincinnati 9 Ohio)
i_imental
corn_pound
MER=I7 (Fr_Lel)_
•_
development of LSD=25 psychosis_
a new blocking a_ent against,
Psychiatro
Reso
Rep oi_140(1955)o
A film was made portraying
_ing
75kgo
three experiments
on a normal subject
"_ _,_iment Noo]_ One hour after lOOz4g LSD orally9 complaints of dry
_th,
muscle tension_ attention defect° After 2 hours9 paranoid
_ctionso
After 2_ hours_ visual hallucinations_ apprehensive 9 marked
_occupation9
communication difficult° Subsequently9 progressive
|mychomotor retardation° After 6 hours_ almost complete catatonic
withdrawal° After 8 hours_ slight improvement° The subject continued
%0
be
confused and to harbour suspicion even 15 hours after the
_ammencement
of the experiment o
IkINariment NoP2_
5 mg Frenquel boiodo for one week° After
injection
100/_g LSD_ the subject, remained his amiable self_ had no dissoci=
minion of: thought and observed no hallucinatory phenomena° Frenquel
did
not block the visceral effects of LSD (dryness of the mouth_
mmumea_ anorexia_
etco)
_;iment
Noo_
lO0/_g LSD orallyo No Frenquel pre_medicationo
_withdrawn9
paranoid_ almost catatonic reaction as in the first
_perimento
After 5 hours the subject was given lO mg Frenquel ioVo
Within a matter of minutes his expression changed and he became more
amimmtedo However_ some suspiciousness
remained° After 15 minutes9
_e accepted another io_ o injection of i0 mg Frenquelo "The psychosis
mmlted tunder our eyes_o After
5
min.utes_ confusion was less marked°
After 12 minutes_ he
reported
"getting things back in shape again"<_
After 17 minutes_ he felt "like waking up from a fever"o After
30
and
60 mlnutes._ complete
restitution_D
normal°
The film also contains a short r4sum4 of
results
obtained with
in acute schizophrenia_ alcoholic hallucinos_.s_ senile
hallucinatory states and chronic schizophrenia°
_l_ql/el
COIIBIT:,
FABING has already
reported
on the blocking effect of
l_remquel on the psychotic effect of LSD (LSD Noo76_ LSD Noo107)_
NKT/bh 156 _

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