1955_grassi_4266_1.pdf

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*VI LSD No. 390 (§iC_a)
M 500 Effect on Z 250 Carcino-
sarcoma
GRASSI, G., MOR, C., PACILLI, N. (Ist.di Farmacol. della Univ.
di Milano; Prof.E.Trabucchi)
Effetto di sostanze desensibilizzanti
sulla c_escita del car-
cinosarcoma di Walker traplantato in sedi diverse. (Effects of
desensitising substances on the growth of Walker's carcino-
sarcoma transplanted to various sites.)
Giorn.ital.chemoterap.
2, 192 (1955).
A study was made in rats of the effects of desensitising
saostances (cortisone, glucose-l-phosphate,
cystamine, sero-
tonin and LSD) on the growth of Walker's carcinosarcoma pre-
viously transplanted to subcutaneous tissues or to the spleen.
Cortisone and glucose-l-phosphate
stimulated the growth of tu-
mours transplanted to both sites. Cystamine, serotonin and LSD
impaired the development of the tumour transplanted to sub-
cutaneous tissue but did not affect the growth of the tumour
transplanted to the spleen,
w6 (E Ii'644) N__r/ev 1057
r
No.
of rats
tumour trans-
planted
to
treatment
f
iNo. of
days
mean
weighti va-
of tu-riance
mour
%
28
16
18
19
12
12
14
12
12
12
14
14
spleen
-
"
cortisone 20mg/kg
"
glucose-l-phos-
phate 20 mg/k
"
cystamine 20m_/kg
"
serotonin Img/kg
"
LSD 5/__g/kg
s.c.
-
"
cortisone 20mg/kg
"
glucose-l-phos-
phate 20 mg/kg
"
cystamine 20 mg/kg
"
serotonin 2 mg/kg
"
LSD 5
,_g/kg
25
25
25
25
25
25
25
25
25
25
25
25
7.7
8.8
8.2
7.8
8.2
7.9
4.1
5.2
4.6
2.7
3.68
3.31
-
+ 14,3
+
+
+
+
5.2
1.3
5.2
2.6
-
+ 26.9
+ 12.2
_
34.4
12.2
19.6

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